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Introduces the principles and practical applications of electron microscopy analytical methods for ceramics, electronic materials, polymers and biological materials. Includes theories of instruments and hands on laboratory experience in their use. 
 
Designed to provide graduate students and senior undergraduate students with an understandingof the principles and the theory of analytical measurements and instrumentation. The course isdivided into three sections consisting of a) analytical measurements including potentiometry andvoltammetry, b) spectrophotometric measurements (i.e. molecular spectrometry), and c) ionicequilibria and statistics. This course is required for graduate programs in Analytical Chemistryand Environmental Studies (Ph.D.) and is recommended for students in other graduate programssuch as Biology, Biochemistry and Environmental Studies (MS) and other areas of chemistry.
 
Covers chemical processes and measurements in marine and estuarine systems. Emphasis isplaced on water column processes; however, air-water and sediment-water interface phenomenaare covered as well. Topics include but are not limited to: ionic equilibria, trace metalcomplexation, redox processes, mathematical modeling applied to chemical systems, and oceanographic sampling. 
 
Provides insight into how reactions occur and how reaction mechanisms are studied. Emphasis is placed on bonding, structure and reactivity. Conformational analysis and stereoelectronic effects, including an introduction to the application of computational chemistry to these subjects.
 
Mechanism, scope and limitations of important selected types of reactions and design of synthetic sequences. Emphasis is placed on methodology of synthesis and current literature. 
 
Introduces the principles and practical applications of scanning probe microscopy and X-ray diffraction methods for ceramics, electronic materials, polymers, and biological materials. Handson laboratory sessions provide details of the operation of the instrumentation involved.
 
Coverage directed to the performance of packed and capillary column for gas chromatography and HPLC. Modern injection, detector and pumping systems used in chromatography are also discussed. 
 
Extension of introductory physical chemistry. Open to undergraduates and graduate students in chemistry and related fields. Emphasis is placed on classical and statistical thermodynamics; surface and colloid chemistry; and electronic and vibration-rotation spectra.
 
Selected topics and recent advances in physical chemistry. Selection of topics is at the discretion of the instructor. 
 
Discussion of various biochemical reactions from the point of view of organic reaction mechanisms. Kinetics, coenzymes and methods of the study of enzyme and catalysis and mechanisms are emphasized.
 
A theoretical treatment of atomic structure and chemical bonds, included are such topics as Russell Saunders' coupling, molecular orbital theory, ligand field theory, and descriptive coordination chemistry. 
 
An advanced study of the structure and properties of proteins, nucleic acids, carbohydrates and lipids, including kinetics and mechanisms of enzyme action and detailed description of metabolic pathways of carbohydrates and lipids.
 
A continuation of 84.550 with emphasis on metabolic pathways of amino acids and nucleic acid, biosynthesis of proteins and selected topics in molecular biology and various areas of biochemistry. 
 
 
Physical chemistry encompasses a group of principles and methods helpful in solving many different types of problems. This course will present selected principles of thermodynamics,kinetics, statistical thermodynamics and quantum mechanics as they are applied to biochemicalsystems. Various experimental techniques will be strongly emphasized in view of their importancein biochemical research. 
 
Pharmaceutical Biochemistry examines the biochemical and molecular mechanisms of drug interaction. Topics include basic aspects of molecular complementarity (molecular recognition), specificity and stability of ligand binding (energetus), as well as crystallographic and computational approaches.
 
Pre-Req: 84.550 Biochemistry I
 
Covers the proof of structure of various types of natural products, approaches to the total synthesis of these products and the biosynthetic pathways. 
 
This course will provide and introductory survey of the basis of theory/simulations of biomolecules. It is accessible to anyone who has completed two semesters of undergraduate chemistry and who has some background in physical chemistry. Topics/examples will be borrowed from modern biological chemistry and biophysics of single biomolecules. The course will be useful for senior undergraduates and beginning graduate students. Chem/Bioinformatics 84.567 will attempt to cultivate computational skills, which on needs to tackle current scientific problems of biology and biophysics.
 
Practical applications of instrumental data in the determination of the structure of organic compounds and polymers. Includes mass spectrometry, ultra-violet spectroscopy, infrared spectroscopy and nuclear magnetic resonance spectroscopy. Open to undergraduate students with permission. 
 
This course outlines the assembly process, structural and functional attributes of protein. Special attention will be given to three-dimensional structures, folding, post translational modifications, misfolding and degradations, as well as biochemical and biophysical techniques used to elucidate protein structure and function.
 
 
 
Analytical biochemistry involves the separation, detection, and analysis of biological molecules. This course addresses advanced theory and applications of contempory biochemical techniques and instrumentation. Topics covered include chromatographic and electrophoretic separation techniques, detection of biomolecules by spectroscopy and radiochemical methods, biological preparations, and structural analysis of proteins, nucleic acids, polysaccharides and lipids.
 
Pre or Co-Req: 84.550 Biochemistry I
 
Required of all graduate students. Presentation of current topics by graduate students. 
 
Required of all graduate students. Presentation of current topics by graduate students.
 
Required of all graduate students. Presentation of current topics by visiting scientists and staff. 
 
Required of all graduate students. Presentation of current topics by visiting scientists and staff.
 
84.641 Co-Op InternshipCredits: 0-1
Practical training for International Students in a Co-operative agreement with Industry or a Government Laboratory for 1 semester. 
 
Advanced topics in various fields of chemistry. Content may vary from year to year so that students may, by repeated enrollment, acquire a broad knowledge of contemporary chemistry.
 
 
 
Surface and colloid chemistry describes the nanoscopic and mesoscopic regimes that connect molecular and macroscopic length scales. The course focuses on how phenomena at macroscopic surfaces and interfaces arise from molecular interactions. Intermolecular and surface forces discussed in detail include van der Waals and electrostatic forces, and how these together with steric interactions give rise to different molecular aggregates (self-assembled structures of surface active molecules and polymers) in bulk solution and in the vicinity of solid surfaces. Examples of modern experimental techniques for measurements of surface forces and for characterization of surfaces and aggregates are discussed and demonstrated.
 
 
 
Continued research project supplementing the research credits for a doctoral student. This course will require special permission from the Graduate Coordinator.
 
 
 
Continued research project supplementing the research credits for a doctoral student. This course will require special permission from the Graduate Coordinator.
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
A study of the principles of condensation, free radical, ionic, coordination and ring opening polymerization. The topics include the effect of polymerization techniques on reaction kinetics and molecular weight, and the evaluation of reactivity ratios in copolymerization reactions.
 
Introduction to chain statistics and thermodynamics of macromolecular solutions, methods of study of molecular weight and chain conformation, and the properties of polymers in bulk including viscoelasticity and crystallinity. 
 
An advanced laboratory in polymer science concerned with the synthesis and characterization of macromolecules.
 
97.511 BiopolymersCredits: 3
Topics include conformation and configuration of vinyl polymers and polypeptides, energetics of chain folding and examination of the forces dictating ordered structures, helix to coil transitions in biopolymers with emphasis on polypeptide structures, instrumental analysis of biopolymer conformation, synthesis of biopolymers including polypeptides, polysaccarides and polynucleotides, and examination of relationships between synthetic polymers and naturally occurring polymers. 
 
An advanced study in polymer science concerned with the synthesis of macromolecules and their mechanisms of formation.
 
Required of all Polymer Science graduate students. Presentation of current topics in polymer science by graduate students. 
 
Required of all Polymer Science graduate students. Presentation of current topics in polymer science by graduate students.
 
Required of all Polymer Science graduate students. Presentation of current topics in polymer science by visiting scientists and staff. 
 
Required of all Polymer Science graduate students. Presentation of current topics in polymer science by visiting scientists and staff.
 
This course is an introduction to the fundamental science and potential applications of conjugated polymers in optical and electronic technologies. The topics covered include history, synthesis and molecular structure, including solid state polymerization; crystallinity and morpholgy, including assembly methods; electronic structure including energy bands, conjugation defects and photoelectron spectroscopy; properties of the insulating forms including light absorption and emission, thermochromism, carrier transport, electroluminescence and nonlinear optical properties; properties of the conducting forms, including ""doping""; some specific devices. 
 
 
 
 
 
 
 
 
 
 
 
97.751 Thesis ReviewCredits: 1
This is a one credit thesis review course. 
 
 
 
 
 
 
 
 
 
 

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