BIOL.4892 Crystallography and Structural Bioinformatics
Id: 041663
Credits: 3-3
Description
This course provides grounding in the principles and practice of protein x-ray crystallography, with some applications in structural bioinformatics and drug discovery. This course is comprised of a series of lecture with an emphasis on practical methodologies of modern protein crystallography and structural bioinformatics. The course will cover the fundamental knowledge about x-ray physics, instrumentation and geometrical diffraction, protein crystallization, macromolecular data collection and processing, phase estimation and improvement, model building and assessment, and some exploration of bioinformatics tools employed in structure prediction and molecular docking.
Prerequisites
BIOL.2055 Introduction to Bioinformatics or BIOL.2200 Principles of Cellular Biology, or Permission of Instructor
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Course prerequisites/corequisites are determined by the faculty and approved by the curriculum committees. Students are required to fulfill these requirements prior to enrollment. For courses offered through online or GPS delivery, students are responsible for confirming with the instructor or department that all enrollment requirements have been satisfied before registering.